Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

Cellular metabolic memory occurs in diabetic microvascular and macrovascular complications, but the underlying mechanisms remain unclear. Here, we investigate the role of sirtuin 1 (SIRT1) and metformin in this phenomenon. In bovine retinal capillary endothelial cells (BRECs) and retinas of diabetic...

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Detalles Bibliográficos
Autores principales: Zheng, Zhi, Chen, Haibing, Li, Jun, Li, Tao, Zheng, Bingqing, Zheng, Ying, Jin, Huiyi, He, Ying, Gu, Qing, Xu, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237662/
https://www.ncbi.nlm.nih.gov/pubmed/22124463
http://dx.doi.org/10.2337/db11-0416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237662/
https://www.ncbi.nlm.nih.gov/pubmed/22124463
http://dx.doi.org/10.2337/db11-0416

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