Mapping Intact Protein Isoforms in Discovery Mode Using Top Down Proteomics

A full description of the human proteome relies on the challenging task of detecting mature and changing forms of protein molecules in the body. Large scale proteome analysis(1) has routinely involved digesting intact proteins followed by inferred protein identification using mass spectrometry (MS)(...

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Detalles Bibliográficos
Autores principales: Tran, John C., Zamdborg, Leonid, Ahlf, Dorothy R., Lee, Ji Eun, Catherman, Adam D., Durbin, Kenneth R., Tipton, Jeremiah D., Vellaichamy, Adaikkalam, Kellie, John F., Li, Mingxi, Wu, Cong, Sweet, Steve M. M., Early, Bryan P., Siuti, Nertila, LeDuc, Richard D., Compton, Philip D., Thomas, Paul M., Kelleher, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237778/
https://www.ncbi.nlm.nih.gov/pubmed/22037311
http://dx.doi.org/10.1038/nature10575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237778/
https://www.ncbi.nlm.nih.gov/pubmed/22037311
http://dx.doi.org/10.1038/nature10575

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