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Mapping Intact Protein Isoforms in Discovery Mode Using Top Down Proteomics
A full description of the human proteome relies on the challenging task of detecting mature and changing forms of protein molecules in the body. Large scale proteome analysis(1) has routinely involved digesting intact proteins followed by inferred protein identification using mass spectrometry (MS)(...
Autores principales: | Tran, John C., Zamdborg, Leonid, Ahlf, Dorothy R., Lee, Ji Eun, Catherman, Adam D., Durbin, Kenneth R., Tipton, Jeremiah D., Vellaichamy, Adaikkalam, Kellie, John F., Li, Mingxi, Wu, Cong, Sweet, Steve M. M., Early, Bryan P., Siuti, Nertila, LeDuc, Richard D., Compton, Philip D., Thomas, Paul M., Kelleher, Neil L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237778/ https://www.ncbi.nlm.nih.gov/pubmed/22037311 http://dx.doi.org/10.1038/nature10575 |
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