Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

Human melanomas show oncogenic B-Raf mutations which activate the B-Raf/MKK/ERK cascade. We screened microarrays to identify cellular targets of this pathway, and found that genes upregulated by B-Raf/MKK/ERK showed highest association with cell cycle regulators, whereas genes downregulated were mos...

Descripción completa

Detalles Bibliográficos
Autores principales: Argast, Gretchen M., Croy, Carrie H., Couts, Kasey L., Zhang, Zhiyong, Litman, Elizabeth, Chan, Daniel C., Ahn, Natalie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238492/
https://www.ncbi.nlm.nih.gov/pubmed/19483722
http://dx.doi.org/10.1038/onc.2009.133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238492/
https://www.ncbi.nlm.nih.gov/pubmed/19483722
http://dx.doi.org/10.1038/onc.2009.133

Ejemplares similares