Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells

Aptamers binding proteins or small molecules have been shown to be versatile and powerful building blocks for the construction of artificial genetic switches. In this study, we present a novel aptamer-based construct regulating the Tet Off system in a tetracycline-independent manner thus achieving c...

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Detalles Bibliográficos
Autores principales: Ausländer, David, Wieland, Markus, Ausländer, Simon, Tigges, Marcel, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239198/
https://www.ncbi.nlm.nih.gov/pubmed/21984476
http://dx.doi.org/10.1093/nar/gkr829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239198/
https://www.ncbi.nlm.nih.gov/pubmed/21984476
http://dx.doi.org/10.1093/nar/gkr829

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