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Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells
Aptamers binding proteins or small molecules have been shown to be versatile and powerful building blocks for the construction of artificial genetic switches. In this study, we present a novel aptamer-based construct regulating the Tet Off system in a tetracycline-independent manner thus achieving c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239198/ https://www.ncbi.nlm.nih.gov/pubmed/21984476 http://dx.doi.org/10.1093/nar/gkr829 |