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A new weapon against an old target

High expression of folate receptors is characteristic for the effector cell population of synovial macrophages in synovial inflammation. A new drug conjugate, EC0746, targets the folate inhibitor aminopterin to folate receptors. In vitro studies show that this conjugate acts antiproliferatively and...

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Detalles Bibliográficos
Autor principal: Fiehn, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239345/
https://www.ncbi.nlm.nih.gov/pubmed/21861856
http://dx.doi.org/10.1186/ar3392