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Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System

In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we sho...

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Detalles Bibliográficos
Autores principales: Nguyen, Lan K., Muñoz-García, Javier, Maccario, Helene, Ciechanover, Aaron, Kolch, Walter, Kholodenko, Boris N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240587/
https://www.ncbi.nlm.nih.gov/pubmed/22194680
http://dx.doi.org/10.1371/journal.pcbi.1002317