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Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System
In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we sho...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240587/ https://www.ncbi.nlm.nih.gov/pubmed/22194680 http://dx.doi.org/10.1371/journal.pcbi.1002317 |