Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

The breast cancer suppressor BRCA2 is essential for the maintenance of genomic integrity in mammalian cells through its role in DNA repair by homologous recombination (HR). Human BRCA2 is 3,418 amino acids and is comprised of multiple domains that interact with the RAD51 recombinase and other protei...

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Detalles Bibliográficos
Autores principales: Siaud, Nicolas, Barbera, Maria A., Egashira, Akinori, Lam, Isabel, Christ, Nicole, Schlacher, Katharina, Xia, Bing, Jasin, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240595/
https://www.ncbi.nlm.nih.gov/pubmed/22194698
http://dx.doi.org/10.1371/journal.pgen.1002409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240595/
https://www.ncbi.nlm.nih.gov/pubmed/22194698
http://dx.doi.org/10.1371/journal.pgen.1002409

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