A Novel Checkpoint and RPA Inhibitory Pathway Regulated by Rif1

Cells accumulate single-stranded DNA (ssDNA) when telomere capping, DNA replication, or DNA repair is impeded. This accumulation leads to cell cycle arrest through activating the DNA–damage checkpoints involved in cancer protection. Hence, ssDNA accumulation could be an anti-cancer mechanism. Howeve...

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Detalles Bibliográficos
Autores principales: Xue, Yuan, Rushton, Michael D., Maringele, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240596/
https://www.ncbi.nlm.nih.gov/pubmed/22194703
http://dx.doi.org/10.1371/journal.pgen.1002417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240596/
https://www.ncbi.nlm.nih.gov/pubmed/22194703
http://dx.doi.org/10.1371/journal.pgen.1002417

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