Granzyme B Inhibits Vaccinia Virus Production through Proteolytic Cleavage of Eukaryotic Initiation Factor 4 Gamma 3

Cytotoxic T lymphocytes (CTLs) are the major killer of virus-infected cells. Granzyme B (GrB) from CTLs induces apoptosis in target cells by cleavage and activation of substrates like caspase-3 and Bid. However, while undergoing apoptosis, cells are still capable of producing infectious viruses unle...

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Detalles Bibliográficos
Autores principales: Marcet-Palacios, Marcelo, Duggan, Brenda Lee, Shostak, Irene, Barry, Michele, Geskes, Tracy, Wilkins, John A., Yanagiya, Akiko, Sonenberg, Nahum, Bleackley, R. Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240606/
https://www.ncbi.nlm.nih.gov/pubmed/22194691
http://dx.doi.org/10.1371/journal.ppat.1002447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240606/
https://www.ncbi.nlm.nih.gov/pubmed/22194691
http://dx.doi.org/10.1371/journal.ppat.1002447

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