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A Dominant Negative Zebrafish Ahr2 Partially Protects Developing Zebrafish from Dioxin Toxicity

The toxicity by 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) is thought to be caused by activation of the aryl hydrocarbon receptor (AHR). However, our understanding of how AHR activation by TCDD leads to toxic effects is poor. Ideally we would like to manipulate AHR activity in specific tissues and a...

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Detalles Bibliográficos
Autores principales: Lanham, Kevin A., Prasch, Amy L., Weina, Kasia M., Peterson, Richard E., Heideman, Warren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240621/
https://www.ncbi.nlm.nih.gov/pubmed/22194803
http://dx.doi.org/10.1371/journal.pone.0028020