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Intracranial V. cholerae Sialidase Protects against Excitotoxic Neurodegeneration
Converging evidence shows that GD3 ganglioside is a critical effector in a number of apoptotic pathways, and GM1 ganglioside has neuroprotective and noötropic properties. Targeted deletion of GD3 synthase (GD3S) eliminates GD3 and increases GM1 levels. Primary neurons from GD3S−/− mice are resistant...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240658/ https://www.ncbi.nlm.nih.gov/pubmed/22195039 http://dx.doi.org/10.1371/journal.pone.0029285 |