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Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1
Lysosomes move bidirectionally on microtubules, and this motility can be stimulated by overexpression of the small GTPase Arl8. By using affinity chromatography, we find that Arl8-GTP binds to the soluble protein SKIP (SifA and kinesin-interacting protein, aka PLEKHM2). SKIP was originally identifie...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240744/ https://www.ncbi.nlm.nih.gov/pubmed/22172677 http://dx.doi.org/10.1016/j.devcel.2011.10.007 |