Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells

Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show,...

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Detalles Bibliográficos
Autores principales: Li, Hongzhe, Steyger, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240991/
https://www.ncbi.nlm.nih.gov/pubmed/22355674
http://dx.doi.org/10.1038/srep00159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240991/
https://www.ncbi.nlm.nih.gov/pubmed/22355674
http://dx.doi.org/10.1038/srep00159

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