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Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity(†)

G-rich oligonucleotides T30695 (or T30923), with the sequence of (GGGT)(4), and T40214, with the sequence of (GGGC)(4), have been reported to exhibit anti-HIV and anticancer activity. Here we report on the structure of a dimeric G-quadruplex adopted by a derivative of these sequences in K(+) solutio...

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Detalles Bibliográficos
Autores principales: Do, Ngoc Quang, Lim, Kah Wai, Teo, Ming Hoon, Heddi, Brahim, Phan, Anh Tuân
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241632/
https://www.ncbi.nlm.nih.gov/pubmed/21840903
http://dx.doi.org/10.1093/nar/gkr539