A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

Sequence-specific nucleases represent valuable tools for precision genome engineering. Traditionally, zinc-finger nucleases (ZFNs) and meganucleases have been used to specifically edit complex genomes. Recently, the DNA binding domains of transcription activator-like effectors (TALEs) from the bacte...

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Detalles Bibliográficos
Autores principales: Mussolino, Claudio, Morbitzer, Robert, Lütge, Fabienne, Dannemann, Nadine, Lahaye, Thomas, Cathomen, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241638/
https://www.ncbi.nlm.nih.gov/pubmed/21813459
http://dx.doi.org/10.1093/nar/gkr597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241638/
https://www.ncbi.nlm.nih.gov/pubmed/21813459
http://dx.doi.org/10.1093/nar/gkr597

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