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A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
Sequence-specific nucleases represent valuable tools for precision genome engineering. Traditionally, zinc-finger nucleases (ZFNs) and meganucleases have been used to specifically edit complex genomes. Recently, the DNA binding domains of transcription activator-like effectors (TALEs) from the bacte...
Autores principales: | Mussolino, Claudio, Morbitzer, Robert, Lütge, Fabienne, Dannemann, Nadine, Lahaye, Thomas, Cathomen, Toni |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241638/ https://www.ncbi.nlm.nih.gov/pubmed/21813459 http://dx.doi.org/10.1093/nar/gkr597 |
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