Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway

The Wnt/β-catenin signaling pathway is important for tumor initiation and progression. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-catenin signaling and represents a promising anticancer target. Recently, the antihelminthic drug, niclosamid...

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Detalles Bibliográficos
Autores principales: Lu, Wenyan, Lin, Cuihong, Roberts, Michael J., Waud, William R., Piazza, Gary A., Li, Yonghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241710/
https://www.ncbi.nlm.nih.gov/pubmed/22195040
http://dx.doi.org/10.1371/journal.pone.0029290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241710/
https://www.ncbi.nlm.nih.gov/pubmed/22195040
http://dx.doi.org/10.1371/journal.pone.0029290

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