Cargando…

Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway

The Wnt/β-catenin signaling pathway is important for tumor initiation and progression. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-catenin signaling and represents a promising anticancer target. Recently, the antihelminthic drug, niclosamid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Wenyan, Lin, Cuihong, Roberts, Michael J., Waud, William R., Piazza, Gary A., Li, Yonghe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241710/ https://www.ncbi.nlm.nih.gov/pubmed/22195040 http://dx.doi.org/10.1371/journal.pone.0029290

Ejemplares similares

Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation
por: Li, Yonghe, et al.
Publicado: (2010)

Niclosamide suppresses renal cell carcinoma by inhibiting Wnt/β-catenin and inducing mitochondrial dysfunctions
por: Zhao, Juan, et al.
Publicado: (2016)

New Insights into Wnt–Lrp5/6–β-Catenin Signaling in Mechanotransduction
por: Kang, Kyung Shin, et al.
Publicado: (2015)

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
por: Kategaya, Lorna S., et al.
Publicado: (2009)

The Relationship between LRP6 and Wnt/β-Catenin Pathway in Colorectal and Esophageal Cancer
por: Shishido, Akemi, et al.
Publicado: (2023)

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling
por: Ng, Victoria H., et al.
Publicado: (2023)

N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/β-Catenin Signalling
por: Xu, Ruiyao, et al.
Publicado: (2023)

Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer
por: Arend, Rebecca C., et al.
Publicado: (2016)

Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling
por: Haack, Fiete, et al.
Publicado: (2021)

Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer
por: Arend, Rebecca C., et al.
Publicado: (2018)

Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6
por: Wang, Hanqing, et al.
Publicado: (2022)

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling
por: Piao, Shunfu, et al.
Publicado: (2008)

Niclosamide suppresses Hepatoma cell proliferation via the Wnt pathway
por: Tomizawa, Minoru, et al.
Publicado: (2013)

The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/β-Catenin Signaling in Cancer Cells
por: Lin, Cuihong, et al.
Publicado: (2013)

Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
por: Lemieux, E, et al.
Publicado: (2015)

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
por: Ren, Qian, et al.
Publicado: (2021)

Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis
por: de Winter, Twan J. J., et al.
Publicado: (2021)

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6
por: Wu, Geng, et al.
Publicado: (2009)

TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation
por: Lettini, Giacomo, et al.
Publicado: (2020)

WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer
por: King, Mandy L., et al.
Publicado: (2014)

Editorial: Targeting the Wnt/β-catenin signaling pathway in cancer
por: Patergnani, Simone, et al.
Publicado: (2022)

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts
por: Sebastian, Aimy, et al.
Publicado: (2017)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation
por: Krejci, Pavel, et al.
Publicado: (2012)

The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice
por: Zhao, Tianyu, et al.
Publicado: (2022)

Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells
por: Li, Yonghe, et al.
Publicado: (2016)

Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling
por: Yin, Lina, et al.
Publicado: (2016)

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
por: Mathew, Bini, et al.
Publicado: (2017)

Dissecting Molecular Differences between Wnt Coreceptors LRP5 and LRP6
por: MacDonald, Bryan T., et al.
Publicado: (2011)

Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer
por: Kang, Hee Eun, et al.
Publicado: (2021)

The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer
por: Lee, Kevin, et al.
Publicado: (2017)

KCTD1 Suppresses Canonical Wnt Signaling Pathway by Enhancing β-catenin Degradation
por: Li, Xinxin, et al.
Publicado: (2014)

Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer
por: MO, MIN-LI, et al.
Publicado: (2013)

An LRP5 Receptor with Internal Deletion in Hyperparathyroid Tumors with Implications for Deregulated WNT/β-Catenin Signaling
por: Björklund, Peyman, et al.
Publicado: (2007)

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
por: Jia, Lin, et al.
Publicado: (2019)

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway
por: Jeong, Woo-Jeong, et al.
Publicado: (2018)

Retraction: KCTD1 Suppresses Canonical Wnt Signaling Pathway by Enhancing β-catenin Degradation
Publicado: (2022)

Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors
por: Schweizer, Liang, et al.
Publicado: (2003)

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin
por: Jiang, Yong, et al.
Publicado: (2012)

Regulation of the Low-Density Lipoprotein Receptor-Related Protein LRP6 and Its Association With Disease: Wnt/β-Catenin Signaling and Beyond
por: Jeong, Wonyoung, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dljgk6pa45d6j9ifi09ujfcgfp