Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

The eukaryotic replicative DNA polymerases (Pol α, δ, and ε), and the major DNA mutagenesis enzyme Pol ζ contain two conserved cysteine-rich metal-binding motifs (CysA and CysB) in the C-terminal domain (CTD) of their catalytic subunits. Here, we demonstrate by in vivo and in vitro approaches the pr...

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Detalles Bibliográficos
Autores principales: Netz, Daili J. A., Stith, Carrie M., Stümpfig, Martin, Köpf, Gabriele, Vogel, Daniel, Genau, Heide M., Stodola, Joseph L., Lill, Roland, Burgers, Peter M. J., Pierik, Antonio J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241888/
https://www.ncbi.nlm.nih.gov/pubmed/22119860
http://dx.doi.org/10.1038/nchembio.721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241888/
https://www.ncbi.nlm.nih.gov/pubmed/22119860
http://dx.doi.org/10.1038/nchembio.721

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