Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor

We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) in its apo and InsP(3)-bound conformations. Comparison of these two conformations reveals that LBD's first β-trefoil fold (β-TF1) and armadillo repeat fold (AR...

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Autores principales: Lin, Chun-Chi, Baek, Kyuwon, Lu, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242432/
https://www.ncbi.nlm.nih.gov/pubmed/21892169
http://dx.doi.org/10.1038/nsmb.2112
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author Lin, Chun-Chi
Baek, Kyuwon
Lu, Zhe
author_facet Lin, Chun-Chi
Baek, Kyuwon
Lu, Zhe
author_sort Lin, Chun-Chi
collection PubMed
description We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) in its apo and InsP(3)-bound conformations. Comparison of these two conformations reveals that LBD's first β-trefoil fold (β-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second β-trefoil fold (β-TF2). Whereas apo-LBD may spontaneously transition between gating conformations, InsP(3) binding shifts this equilibrium towards the active state.
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spelling pubmed-32424322012-04-01 Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor Lin, Chun-Chi Baek, Kyuwon Lu, Zhe Nat Struct Mol Biol Article We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) in its apo and InsP(3)-bound conformations. Comparison of these two conformations reveals that LBD's first β-trefoil fold (β-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second β-trefoil fold (β-TF2). Whereas apo-LBD may spontaneously transition between gating conformations, InsP(3) binding shifts this equilibrium towards the active state. 2011-09-04 /pmc/articles/PMC3242432/ /pubmed/21892169 http://dx.doi.org/10.1038/nsmb.2112 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lin, Chun-Chi
Baek, Kyuwon
Lu, Zhe
Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor
title Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor
title_full Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor
title_fullStr Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor
title_full_unstemmed Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor
title_short Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor
title_sort apo and insp(3)-bound crystal structures of the ligand-binding domain of an insp(3) receptor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242432/
https://www.ncbi.nlm.nih.gov/pubmed/21892169
http://dx.doi.org/10.1038/nsmb.2112
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