SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser(382)). WNK isoforms phosphorylate...

Descripción completa

Detalles Bibliográficos
Autores principales: Thastrup, Jacob O., Rafiqi, Fatema H., Vitari, Alberto C., Pozo-Guisado, Eulalia, Deak, Maria, Mehellou, Youcef, Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242505/
https://www.ncbi.nlm.nih.gov/pubmed/22032326
http://dx.doi.org/10.1042/BJ20111879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242505/
https://www.ncbi.nlm.nih.gov/pubmed/22032326
http://dx.doi.org/10.1042/BJ20111879

Ejemplares similares