Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

BACKGROUND: Upregulation of PIM kinase expression has been reported in many malignancies, suggesting that inhibition of PIM kinase activity may be an attractive therapeutic strategy. We hypothesised that inhibition of PIM kinase activity with SGI-1776, a novel small molecule inhibitor of PIM kinase...

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Detalles Bibliográficos
Autores principales: Mahalingam, D, Espitia, C M, Medina, E C, Esquivel, J A, Kelly, K R, Bearss, D, Choy, G, Taverna, P, Carew, J S, Giles, F J, Nawrocki, S T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242528/
https://www.ncbi.nlm.nih.gov/pubmed/22015557
http://dx.doi.org/10.1038/bjc.2011.426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242528/
https://www.ncbi.nlm.nih.gov/pubmed/22015557
http://dx.doi.org/10.1038/bjc.2011.426

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