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Suppression and Regression of Choroidal Neovascularization in Mice by a Novel CCR2 Antagonist, INCB3344

PURPOSE: To investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model of choroidal neovascularization (CNV). METHODS: CNV was induced by laser photocoagulation on Day 0 in wild type mice. INCB3344 or vehicle was administered intravitreally immediately after...

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Detalles Bibliográficos
Autores principales: Xie, Ping, Kamei, Motohiro, Suzuki, Mihoko, Matsumura, Nagakazu, Nishida, Kentaro, Sakimoto, Susumu, Sakaguchi, Hirokazu, Nishida, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242774/
https://www.ncbi.nlm.nih.gov/pubmed/22205983
http://dx.doi.org/10.1371/journal.pone.0028933