The Combination of Early and Rapid Type I IFN, IL-1α, and IL-1β Production Are Essential Mediators of RNA-Like Adjuvant Driven CD4+ Th1 Responses

There is a growing need for novel vaccine adjuvants that can provide safe and potent T-helper type 1 (Th1) activity. RNA-like immune response modifiers (IRMs) are candidate T-cell adjuvants that skew acquired immune responses towards a Th1 phenotype. We set out to delineate the essential signaling p...

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Detalles Bibliográficos
Autores principales: Madera, Rachel F., Wang, Jennifer P., Libraty, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242790/
https://www.ncbi.nlm.nih.gov/pubmed/22206014
http://dx.doi.org/10.1371/journal.pone.0029412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242790/
https://www.ncbi.nlm.nih.gov/pubmed/22206014
http://dx.doi.org/10.1371/journal.pone.0029412

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