Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats

BACKGROUND AND PURPOSE: Sclerostin is produced by osteocytes and is an inhibitor of bone formation. Thus, inhibition of sclerostin by a monoclonal antibody increases bone formation and improves fracture repair. Sclerostin expression is upregulated in unloaded bone and is downregulated by loading. We...

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Detalles Bibliográficos
Autores principales: Agholme, Fredrik, Isaksson, Hanna, Li, Xiaodong, Ke, Hua Zhu, Aspenberg, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242963/
https://www.ncbi.nlm.nih.gov/pubmed/22103277
http://dx.doi.org/10.3109/17453674.2011.625539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242963/
https://www.ncbi.nlm.nih.gov/pubmed/22103277
http://dx.doi.org/10.3109/17453674.2011.625539

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