Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion

PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity. We aimed here to identify mutations in the PASK gene that may be associated with young-onset diabetes in humans. We screened 18 diabetic probands with unelucid...

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Detalles Bibliográficos
Autores principales: Semplici, Francesca, Vaxillaire, Martine, Fogarty, Sarah, Semache, Meriem, Bonnefond, Amélie, Fontés, Ghislaine, Philippe, Julien, Meur, Gargi, Diraison, Frederique, Sessions, Richard B., Rutter, Jared, Poitout, Vincent, Froguel, Philippe, Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243507/
https://www.ncbi.nlm.nih.gov/pubmed/22065581
http://dx.doi.org/10.1074/jbc.M111.254995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243507/
https://www.ncbi.nlm.nih.gov/pubmed/22065581
http://dx.doi.org/10.1074/jbc.M111.254995

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