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Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

Mechanotransduction is a critical function for cells, in terms of cell viability, shaping of tissues, and cellular behavior. In vitro, cellular level forces can stretch adhesion proteins that link extracellular matrix to the actin cytoskeleton exposing hidden binding sites. However, there is no evid...

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Detalles Bibliográficos
Autores principales: Margadant, Felix, Chew, Li Li, Hu, Xian, Yu, Hanry, Bate, Neil, Zhang, Xian, Sheetz, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243729/
https://www.ncbi.nlm.nih.gov/pubmed/22205879
http://dx.doi.org/10.1371/journal.pbio.1001223