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Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha
Amiodarone [2-butyl-3-(3′,5′-diiodo-4’α-diethylaminoethoxybenzoyl)-benzofuran] (AMD), a class III antiarrhythmic drug, is known to cause idiosyncratic hepatotoxic reactions in human patients. One hypothesis for the etiology of idiosyncratic adverse drug reactions is that a concurrent inflammatory st...
Main Authors: | , , , , |
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Format: | Online Article Text |
Language: | English |
Published: |
Oxford University Press
2012
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Subjects: | |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243747/ https://www.ncbi.nlm.nih.gov/pubmed/21984482 http://dx.doi.org/10.1093/toxsci/kfr266 |