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Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional Activities

Human APOBEC3 (A3) proteins are cellular cytidine deaminases that potently restrict the replication of retroviruses by hypermutating viral cDNA and/or inhibiting reverse transcription. There are seven members of this family including A3A, B, C, DE, F, G, and H, all encoded in a tandem array on human...

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Detalles Bibliográficos
Autores principales: Kitamura, Shingo, Ode, Hirotaka, Iwatani, Yasumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243911/
https://www.ncbi.nlm.nih.gov/pubmed/22203821
http://dx.doi.org/10.3389/fmicb.2011.00258