Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR from Cμ to Cγ1 (IgG1) and Cε (IgE), the latter of which contributes t...

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Detalles Bibliográficos
Autores principales: Wesemann, Duane R., Magee, Jennifer M., Boboila, Cristian, Calado, Dinis Pedro, Gallagher, Michael P., Portuguese, Andrew J., Manis, John P., Zhou, Xiaolong, Recher, Mike, Rajewsky, Klaus, Notarangelo, Luigi D., Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244039/
https://www.ncbi.nlm.nih.gov/pubmed/22143888
http://dx.doi.org/10.1084/jem.20111155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244039/
https://www.ncbi.nlm.nih.gov/pubmed/22143888
http://dx.doi.org/10.1084/jem.20111155

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