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Systematic Drug Repositioning Based on Clinical Side-Effects

Drug repositioning helps fully explore indications for marketed drugs and clinical candidates. Here we show that the clinical side-effects (SEs) provide a human phenotypic profile for the drug, and this profile can suggest additional disease indications. We extracted 3,175 SE-disease relationships b...

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Detalles Bibliográficos
Autores principales: Yang, Lun, Agarwal, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244383/
https://www.ncbi.nlm.nih.gov/pubmed/22205936
http://dx.doi.org/10.1371/journal.pone.0028025