Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure

Thiopurine methyltransferase (Tpmt) is the primary enzyme responsible for deactivating thiopurine drugs. Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the treatment of cancer, organ transplant, and autoimmune disorders. Chronic thiopurine therapy has b...

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Detalles Bibliográficos
Autores principales: Hosni-Ahmed, Amira, Barnes, Joseph D., Wan, Jim, Jones, Terreia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244435/
https://www.ncbi.nlm.nih.gov/pubmed/22216194
http://dx.doi.org/10.1371/journal.pone.0029163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244435/
https://www.ncbi.nlm.nih.gov/pubmed/22216194
http://dx.doi.org/10.1371/journal.pone.0029163

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