A Short Caspase-3 Isoform Inhibits Chemotherapy-Induced Apoptosis by Blocking Apoptosome Assembly

Alternative splicing of caspase-3 produces a short isoform caspase-3s that antagonizes caspase-3 apoptotic activity. However, the mechanism of apoptosis inhibition by caspase-3s remains unknown. Here we show that exogenous caspase-3 sensitizes MCF-7 and HBL100 breast cancers cells to chemotherapeuti...

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Detalles Bibliográficos
Autores principales: Végran, Frédérique, Boidot, Romain, Solary, Eric, Lizard-Nacol, Sarab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245238/
https://www.ncbi.nlm.nih.gov/pubmed/22216167
http://dx.doi.org/10.1371/journal.pone.0029058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245238/
https://www.ncbi.nlm.nih.gov/pubmed/22216167
http://dx.doi.org/10.1371/journal.pone.0029058

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