Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments

Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a trinucleotide (CAG)(n) repeat expansion in the coding sequence of the huntingtin gene, and an expanded polyglutamine (>37Q) tract in the protein. This results in misfolding and accumulation of hunt...

Descripción completa

Detalles Bibliográficos
Autores principales: Butler, David C., Messer, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245261/
https://www.ncbi.nlm.nih.gov/pubmed/22216210
http://dx.doi.org/10.1371/journal.pone.0029199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245261/
https://www.ncbi.nlm.nih.gov/pubmed/22216210
http://dx.doi.org/10.1371/journal.pone.0029199

Ejemplares similares