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Increased Renal Methylglyoxal Formation with Down-Regulation of PGC-1α-FBPase Pathway in Cystathionine γ-Lyase Knockout Mice

We have previously reported that hydrogen sulfide (H(2)S), a gasotransmitter and vasodilator has cytoprotective properties against methylglyoxal (MG), a reactive glucose metabolite associated with diabetes and hypertension. Recently, H(2)S was shown to up-regulate peroxisome proliferator-activated r...

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Detalles Bibliográficos
Autores principales: Untereiner, Ashley A., Dhar, Arti, Liu, Jianghai, Wu, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245291/
https://www.ncbi.nlm.nih.gov/pubmed/22216325
http://dx.doi.org/10.1371/journal.pone.0029592