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Mutability of prions
Murine prions transferred from brain to cultured cells gradually adapt to the new environment. Brain-derived 22L prions can infect neuroblastoma-derived PK1 cells in the presence of swainsonine (swa); that is, they are ‘swa resistant’. PK1 cell-adapted 22L prions are swa sensitive; however, propagat...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Molecular Biology Organization
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245691/ https://www.ncbi.nlm.nih.gov/pubmed/21997293 http://dx.doi.org/10.1038/embor.2011.191 |