The hERG K(+) channel S4 domain L532P mutation: Characterization at 37 °C

hERG (human Ether-à-go-go Related Gene) is responsible for ion channels mediating rapid delayed rectifier potassium current, I(Kr), which is key to cardiac action potential repolarization. Gain-of-function hERG mutations give rise to the SQT1 variant of the Short QT Syndrome (SQTS). Reggae mutant ze...

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Detalles Bibliográficos
Autores principales: Zhang, Yi H., Colenso, Charlotte K., Sessions, Richard B., Dempsey, Christopher E., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245891/
https://www.ncbi.nlm.nih.gov/pubmed/21777565
http://dx.doi.org/10.1016/j.bbamem.2011.07.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245891/
https://www.ncbi.nlm.nih.gov/pubmed/21777565
http://dx.doi.org/10.1016/j.bbamem.2011.07.001

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