Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4

Thiostrepton, a macrocyclic thiopeptide antibiotic, inhibits prokaryotic translation by interfering with the function of elongation factor G (EF-G). Here, we have used 70S ribosome binding and GTP hydrolysis assays to study the effects of thiostrepton on EF-G and a newly described translation factor...

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Detalles Bibliográficos
Autores principales: Walter, Justin D., Hunter, Margaret, Cobb, Melanie, Traeger, Geoff, Spiegel, P. Clint
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245911/
https://www.ncbi.nlm.nih.gov/pubmed/21908407
http://dx.doi.org/10.1093/nar/gkr623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245911/
https://www.ncbi.nlm.nih.gov/pubmed/21908407
http://dx.doi.org/10.1093/nar/gkr623

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