Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress

Short interfering RNAs (siRNAs) target specific mRNAs for their degradation mediated by RNA-induced silencing complex (RISC). Persistent activation of siRNA-RISC frequently leads to non-targeting toxicity. However, how cells mediate this stress remains elusive. In this communication, we found that t...

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Detalles Bibliográficos
Autores principales: Wei, Pei-Chi, Lo, Wen-Ting, Su, Mei-I., Shew, Jin-Yuh, Lee, Wen-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245931/
https://www.ncbi.nlm.nih.gov/pubmed/21908404
http://dx.doi.org/10.1093/nar/gkr714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245931/
https://www.ncbi.nlm.nih.gov/pubmed/21908404
http://dx.doi.org/10.1093/nar/gkr714

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