Optimized detection of transcription factor-binding sites in ChIP-seq experiments

We developed a computational procedure for optimizing the binding site detections in a given ChIP-seq experiment by maximizing their reproducibility under bootstrap sampling. We demonstrate how the procedure can improve the detection accuracies beyond those obtained with the default settings of popu...

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Detalles Bibliográficos
Autores principales: Elo, Laura L., Kallio, Aleksi, Laajala, Teemu D., Hawkins, R. David, Korpelainen, Eija, Aittokallio, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245948/
https://www.ncbi.nlm.nih.gov/pubmed/22009681
http://dx.doi.org/10.1093/nar/gkr839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245948/
https://www.ncbi.nlm.nih.gov/pubmed/22009681
http://dx.doi.org/10.1093/nar/gkr839

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