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Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases

The cholesterol ozonolysis products secosterol-A and its aldolization product secosterol-B were recently detected in human atherosclerotic tissues and brain specimens, and have been postulated to play pivotal roles in the pathogenesis of atherosclerosis and neurodegenerative diseases. We examined se...

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Detalles Bibliográficos
Autores principales: Lai, Ying-Ling, Tomono, Susumu, Miyoshi, Noriyuki, Ohshima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246188/
https://www.ncbi.nlm.nih.gov/pubmed/22247606
http://dx.doi.org/10.3164/jcbn.11-31