Five dysfunctional telomeres predict onset of senescence in human cells

Replicative senescence is accompanied by a telomere-specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early-passage normal human cells and increase in number with increasing cumulative cell divisions. DDR+ telomeres at replicative senescence retain TRF2 and RAP1...

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Detalles Bibliográficos
Autores principales: Kaul, Zeenia, Cesare, Anthony J, Huschtscha, Lily I, Neumann, Axel A, Reddel, Roger R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246253/
https://www.ncbi.nlm.nih.gov/pubmed/22157895
http://dx.doi.org/10.1038/embor.2011.227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246253/
https://www.ncbi.nlm.nih.gov/pubmed/22157895
http://dx.doi.org/10.1038/embor.2011.227

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