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Five dysfunctional telomeres predict onset of senescence in human cells

Replicative senescence is accompanied by a telomere-specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early-passage normal human cells and increase in number with increasing cumulative cell divisions. DDR+ telomeres at replicative senescence retain TRF2 and RAP1...

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Detalles Bibliográficos
Autores principales:	Kaul, Zeenia, Cesare, Anthony J, Huschtscha, Lily I, Neumann, Axel A, Reddel, Roger R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Molecular Biology Organization 2012
Materias:	Scientific Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246253/ https://www.ncbi.nlm.nih.gov/pubmed/22157895 http://dx.doi.org/10.1038/embor.2011.227

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