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Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK)
The hypoxic and acidic microenvironments in tumors are strongly associated with malignant progression and metastasis, and have thus become a central issue in tumor physiology and cancer treatment. Despite this, the molecular links between acidic pH- and hypoxia-mediated cell invasion/metastasis rema...
Autores principales: | Lucien, Fabrice, Brochu-Gaudreau, Karine, Arsenault, Dominique, Harper, Kelly, Dubois, Claire M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246449/ https://www.ncbi.nlm.nih.gov/pubmed/22216126 http://dx.doi.org/10.1371/journal.pone.0028851 |
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