Whole-genome sequencing of rifampicin-resistant M. tuberculosis strains identifies compensatory mutations in RNA polymerase

Drug-resistant bacteria are emerging worldwide, despite frequently being less fit than drug-susceptible strains(1). Data from model systems suggest the fitness cost of antimicrobial resistance can be mitigated by compensatory mutations(2). However, current evidence that compensatory evolution plays...

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Detalles Bibliográficos
Autores principales: Comas, Iñaki, Borrell, Sonia, Roetzer, Andreas, Rose, Graham, Malla, Bijaya, Kato-Maeda, Midori, Galagan, James, Niemann, Stefan, Gagneux, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246538/
https://www.ncbi.nlm.nih.gov/pubmed/22179134
http://dx.doi.org/10.1038/ng.1038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246538/
https://www.ncbi.nlm.nih.gov/pubmed/22179134
http://dx.doi.org/10.1038/ng.1038

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