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Pax3 Stimulates p53 Ubiquitination and Degradation Independent of Transcription
BACKGROUND: Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac neural crest defects in Pax3-mutant mouse embryos. This demonstrates that P...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247257/ https://www.ncbi.nlm.nih.gov/pubmed/22216266 http://dx.doi.org/10.1371/journal.pone.0029379 |