BRCA1 is an essential regulator of heart function and survival following myocardial infarction

The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer but its role in protecting other tissues from DNA damage has not been explored. Here we show a new role for BRCA1 as a gatekeeper of cardiac function and survival. In mice, loss of BRCA1 in cardiomyocytes results in adverse...

Descripción completa

Detalles Bibliográficos
Autores principales: Shukla, Praphulla C., Singh, Krishna K., Quan, Adrian, Al-Omran, Mohammed, Teoh, Hwee, Lovren, Fina, Cao, Liu, Rovira, Ilsa I., Pan, Yi, Brezden-Masley, Christine, Yanagawa, Bobby, Gupta, Aanika, Deng, Chu-Xia, Coles, John G., Leong-Poi, Howard, Stanford, William L., Parker, Thomas G., Schneider, Michael D., Finkel, Toren, Verma, Subodh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247816/
https://www.ncbi.nlm.nih.gov/pubmed/22186889
http://dx.doi.org/10.1038/ncomms1601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247816/
https://www.ncbi.nlm.nih.gov/pubmed/22186889
http://dx.doi.org/10.1038/ncomms1601

Ejemplares similares